Buchet M
11 Feb 2024
Oxidative stress and fibrosis are important stress responses that characterize bronchopulmonary dysplasia (BPD), a disease for which only a therapy but not a cure has been developed
Broncho pulmonary dysplasia (BPD), the most common and severe consequence of preterm birth.
BPD is a severe lung disease that primarily affects extremely premature infants (< 28 weeks gestational age) who require prolonged oxygen therapy to support their breathing. Despite improved perinatal care in developed countries, 40% of extremely pre-term babies develop BPD, the most common and severe consequence of pre-term birth and the most common morbidity of pre-maturity.
Oxidative stress and fibrosis are important stress responses that characterize bronchopulmonary dysplasia (BPD), a disease for which only a therapy but not a cure has been developed.
Intratracheal administration of clinical-grade MSC-EVs protect from oxidative stress, improves pulmonary epithelial function, and counteracts the development of fibrosis. In the future, MSC-EVs could represent a new cure to prevent the development of BPD.